Chemix Sleep

Assist your recovery and induce restfulness with the all new Chemix Ultra Premium Sleep Aid. The Guerrilla Chemist has gone back to the lab and formulated Chemix's first ever Ultra Premium Sleep Aid Product. This one of a kind formulation will turn your lights out when it's time to get your rest. Chemix Sleep will provide the best in rest and recovery with no excess leaving you ready to take on the day with plenty of energy and focus.

SLEEP is an all-natural, multifaceted sleep support supplement designed to promote quality and restful sleep to ensure maximum recovery. Quality sleep is one of the most important and essential actions your body needs to function properly. It is estimated that up to 33% of all adults do not get enough quality sleep. SLEEP is specifically designed to help fight off restlessness via different mechanisms of action, including inducing sleep and staying asleep.

HOW DOES CHEMIX SLEEP WORK?
GABAiclinÔ is a trademarked extract of Scutellaria baicalensis, standardized for 30% of the main active baicalin.

MagnaSleepÔ is an extremely potent form of magnolia bark extract(MBE), standardized for 90% of two powerful active phenolic compounds: magnolol and honokiol. In Chinese and Japanese tradition medicine for help promote sleep a hefty 25mg dose of BioPerineÒ(black pepper extract) was added to inhibit this process.

Cussonia zimmermannii is an African herb. The rootbark extract of C. zimmermannii has some very unique compounds known as polyacetylenes. These compounds have been shown to promote restful sleep, as well as staying asleep longer.

Hesperidin is one of the main bioactive compounds from citrus peel extract.

Apigenin is a polyphenolic flavonoid that is one of the most abundant and well-studied.

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References:

1. Chang HH, Yi PL, Cheng CH, et al. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. J Ethnopharmacol. 2011;135(2):359-368.
2. Shi, Yuan, et al. "Herbal insomnia medications that target GABAergic systems: a review of the psychopharmacological evidence." Current Neuropharmacology3 (2014): 289-302.
3. Ai, Jinglu, Xiaomei Wang, and Mogens Nielsen. "Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro." Pharmacology1 (2001): 34-41.
4. Squires, Richard F., et al. "Honokiol and magnolol increase the number of [3 H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites." Neurochemical research12 (1999): 1593-1602.
5. Chen, Chang-Rui, et al. "Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABAA receptor in mice." Neuropharmacology6 (2012): 1191-1199.
6. Senn, Martin W. Structures and evaluation of biologically active constituents of" Cussonia Zimmermannii" harms. Diss. University_of_Basel, 2006.
7. Martínez, M. Cecilia, et al. "Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice." Pharmacology Biochemistry and Behavior2 (2009): 291-296.
8. Fernández, Sebastián P., et al. "Synergistic interaction between hesperidin, a natural flavonoid, and diazepam." European journal of pharmacology2-3 (2005): 189-198.
9. Fernández, Sebastián, et al. "Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis." Pharmacology Biochemistry and Behavior2 (2004): 399-404.
10. Salehi, Bahare, et al. "The therapeutic potential of apigenin." International journal of molecular sciences6 (2019): 1305.
11. Kim, Jae-Wook, et al. "Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation." Archives of pharmacal research2 (2012): 367-373.
12. Gazola, Andressa C., et al. "Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from Passiflora quadrangularis pericarp." Revista Brasileira de Farmacognosia 25.2 (2015): 158-163.